Opportunity Information: Apply for W81XWH 18 PRCRP TTSA
The DoD Peer Reviewed Cancer Research Program (PRCRP) Translational Team Science Award (TTSA) is a fiscal year 2018 funding opportunity from the Department of Defense (U.S. Army Medical Research Acquisition Activity) designed to push promising cancer findings closer to real-world clinical use. The program is specifically aimed at hypothesis-driven translational research that is already grounded in clinical evidence, meaning applicants are expected to build on results coming out of clinical investigations rather than starting from early discovery work. Projects are expected to be tied to an ongoing or completed clinical trial and/or to rely on existing annotated biorepositories (collections of human samples that include linked clinical and outcome data). The overall intent is to support the kind of advanced translational work that directly informs a next-phase clinical trial or a near-term clinical application, such as improving how cancer is prevented, detected, diagnosed, treated, or managed during survivorship.
A defining feature of the TTSA is that it funds team-based science rather than single-lab projects. Applications must be led by a collaboration of at least two, and no more than three, Principal Investigators working under one integrated research plan. The funding logic here is that meaningful translation typically requires multiple disciplines, for example clinicians, translational scientists, biomarker experts, statisticians, and outcomes researchers all contributing essential pieces. The DoD strongly encourages including at least one military or Department of Veterans Affairs (VA) investigator as an equal research partner with real intellectual and workload commitments. This includes active duty or reserve personnel, DoD civilian investigators, or investigators based at VA research facilities. Importantly, the military or VA collaborator is not supposed to be a token addition simply to gain access to military or VA patient populations; they are expected to play a substantial scientific role.
The translational expectation is also explicit. Proposals need to show two-way movement between basic and clinical science, such as using clinical observations to refine mechanistic hypotheses and then returning those insights back to the clinic through validation, stratification tools, or trial-ready approaches. The program emphasizes leveraging clinical information to close critical knowledge gaps that affect patient outcomes, validate key results that look promising but still need confirmation in clinically relevant settings, expand upon potentially game-changing clinical signals, or investigate new clinical findings that could alter practice. While the award can support clinical trials, the opportunity is not meant to function as a clinical trial-only funding mechanism; rather, it supports broader clinical research studies conducted by multidisciplinary teams where a trial may be one component of a larger translational package.
For FY18, the TTSA highlights several encouraged research directions: patient-reported outcomes, survivorship, and quality of life; the relationship between prevention strategies and long-term (longitudinal) cancer risk outcomes; and risk stratification for both primary cancers and metastatic disease. In practical terms, this means the DoD is especially interested in studies that help predict who is most at risk, who is most likely to benefit from specific interventions, and how cancer and its treatment affect patients over time, including functional outcomes that matter to patients but may not be captured by traditional clinical endpoints.
The mechanism is flexible in terms of research materials and platforms. Studies may involve animal models, human subjects, and/or human anatomical substances, and the development or use of relevant preclinical models can be included when it directly supports translation to clinical application. At the same time, the TTSA is not intended to support large-scale high-throughput activities such as broad screening or sequencing efforts as a primary project focus. The expectation is that applicants have a targeted, hypothesis-driven plan anchored to clinical relevance, rather than an exploratory data-generation approach.
Military relevance is a required element. Proposed work must address at least one FY18 PRCRP Military Relevance Focus Area and demonstrate clear relevance to active duty Service members, Veterans, and other military beneficiaries. The program also notes broader relevance to the American public, but the military connection is central and must be justified in the application. Applicants are directed to PRCRP and military health-related resources (including the Military Health System and VA) for context on military needs and priorities.
From a competitiveness standpoint, preliminary clinical evidence is required. Applicants must include clinical data within the application and/or cite prior relevant clinical work by the investigative team that supports the project rationale and feasibility. This reinforces the program’s emphasis on advanced translation rather than early-stage discovery.
Administratively, the opportunity (Funding Opportunity Number W81XWH-18-PRCRP-TTSA) is offered as a discretionary award mechanism and may be made as a cooperative agreement or grant under CFDA 12.420. Eligibility is broadly unrestricted (open to any entity type, subject to any additional eligibility details in the full announcement). The anticipated cap for direct costs is up to $1,000,000 for the entire period of performance, and the DoD expected to make roughly 10 awards under this solicitation. The original posting date was May 2, 2018, with an original closing date of September 26, 2018.Apply for W81XWH 18 PRCRP TTSA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Peer Reviewed Cancer, Translational Team Science Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on May 02, 2018.
- Applicants must submit their applications by Sep 26, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 10 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Frequently Asked Questions (FAQs)
What is the PRCRP Translational Team Science Award (TTSA)?
The DoD Peer Reviewed Cancer Research Program (PRCRP) Translational Team Science Award (TTSA) is a FY2018 funding opportunity intended to move promising cancer findings closer to clinical use. It supports hypothesis-driven translational research that is already grounded in clinical evidence and is positioned to inform a next-phase clinical trial or near-term clinical application.
What kind of research is this award designed to support?
This mechanism is designed for advanced translational cancer research that connects clinical evidence to practical clinical impact. Projects should leverage clinical observations and data to refine hypotheses and generate outputs that can be validated and moved back into the clinic, such as trial-ready approaches, validation studies, or patient stratification tools.
Does the TTSA fund early discovery or exploratory research?
No. The TTSA is aimed at translational work based on clinical evidence rather than early-stage discovery research. Applicants are expected to build on results coming out of clinical investigations, not to start from preliminary discovery-only findings.
Is clinical evidence required to apply?
Yes. Preliminary clinical evidence is required. Applicants must include clinical data in the application and/or cite prior relevant clinical work by the investigative team that supports the rationale and feasibility of the proposed project.
Do projects need to be connected to a clinical trial?
Yes, projects are expected to be tied to an ongoing or completed clinical trial and/or rely on existing annotated biorepositories that include linked clinical and outcomes data.
Can the project use annotated biorepositories instead of running a clinical trial?
Yes. The opportunity notes that projects may rely on existing annotated biorepositories (human sample collections with linked clinical and outcome data) as a foundation for clinically grounded translational research.
Are clinical trials allowed under this award?
Clinical trials can be supported, but the TTSA is not intended to be a clinical trial-only funding mechanism. The expectation is a broader translational clinical research program led by a multidisciplinary team, where a clinical trial may be one component of a larger package.
What is meant by "two-way" translational research in this program?
The TTSA emphasizes bidirectional movement between clinical and basic science, such as using clinical observations to refine mechanistic hypotheses and then returning insights to the clinic through validation, risk stratification tools, or approaches that are ready for a next-step clinical setting.
What are examples of the types of cancer impacts the TTSA aims to achieve?
The intent is to advance near-term clinical applications that improve how cancer is prevented, detected, diagnosed, treated, or managed during survivorship, including outcomes that matter to patients over time.
Is this a team science mechanism or a single-PI award?
This is explicitly a team science mechanism. Applications must be led by a collaboration of at least two and no more than three Principal Investigators (PIs) working under one integrated research plan.
How many Principal Investigators are required and allowed?
The application must include a minimum of two and a maximum of three Principal Investigators as part of the integrated team.
Why does the program require multiple PIs?
The stated logic is that meaningful translation typically requires multiple disciplines (for example clinicians, translational scientists, biomarker experts, statisticians, and outcomes researchers) contributing essential components to a single integrated plan.
Is a military or VA collaborator required?
The program strongly encourages including at least one military or Department of Veterans Affairs (VA) investigator as an equal research partner, but the information provided describes this as encouraged rather than stated as mandatory.
Who counts as a military or VA investigator for this opportunity?
Examples include active duty or reserve personnel, DoD civilian investigators, or investigators based at VA research facilities.
Can a military or VA investigator be added just to access military or VA patients?
No. The program emphasizes that a military or VA collaborator should not be a token addition. They are expected to have a substantial scientific role, including real intellectual contribution and workload commitments.
What research areas are especially encouraged in FY18 under the TTSA?
The FY18 TTSA highlights encouraged directions that include: (1) patient-reported outcomes, survivorship, and quality of life; (2) relationships between prevention strategies and long-term (longitudinal) cancer risk outcomes; and (3) risk stratification for both primary cancers and metastatic disease.
What does "risk stratification" mean in the context of this opportunity?
In practical terms (as described), the program is interested in studies that help predict who is most at risk and who is most likely to benefit from specific interventions, including in primary cancers and metastatic disease.
Can projects involve patient-reported outcomes and survivorship topics?
Yes. Patient-reported outcomes, survivorship, and quality of life are specifically highlighted as encouraged research directions for FY18.
What does the program say about prevention research?
The FY18 TTSA encourages research examining the relationship between prevention strategies and long-term (longitudinal) cancer risk outcomes.
What types of research materials or platforms are allowed?
The mechanism is described as flexible. Studies may involve animal models, human subjects, and/or human anatomical substances. The development or use of relevant preclinical models may be included when it directly supports translation to a clinical application.
Are large high-throughput screening or sequencing projects a good fit?
Generally no. The TTSA is not intended to support large-scale high-throughput activities (such as broad screening or sequencing) as a primary project focus. The expectation is a targeted, hypothesis-driven plan anchored to clinical relevance.
Is military relevance required?
Yes. Military relevance is a required element. Proposed work must address at least one FY18 PRCRP Military Relevance Focus Area and clearly justify relevance to active duty Service members, Veterans, and other military beneficiaries.
Is the research expected to also benefit the broader public?
The program notes broader relevance to the American public, but it emphasizes that the military connection is central and must be justified in the application.
What is the Funding Opportunity Number (FON) for this solicitation?
The Funding Opportunity Number provided is W81XWH-18-PRCRP-TTSA.
Which agency is offering this opportunity?
The opportunity is from the Department of Defense, administered through the U.S. Army Medical Research Acquisition Activity, under the DoD Peer Reviewed Cancer Research Program (PRCRP).
What type of award is it (grant vs cooperative agreement)?
The solicitation indicates it may be made as either a cooperative agreement or a grant.
What is the CFDA number associated with this opportunity?
The CFDA number listed is 12.420.
Who is eligible to apply?
Eligibility is described as broadly unrestricted (open to any entity type), subject to any additional eligibility details that would be included in the full announcement.
What is the maximum funding level?
The anticipated cap for direct costs is up to $1,000,000 for the entire period of performance.
How many awards does DoD expect to make?
The DoD expected to make roughly 10 awards under this FY18 solicitation.
What were the original posting and closing dates for FY18?
The original posting date was May 2, 2018, and the original closing date was September 26, 2018.
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