Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R01 Clinical Trial Not Allowed) | PAR 25 095

Opportunity Information: Apply for PAR 25 095

The National Institutes of Health (NIH), led by the National Cancer Institute (NCI) and joined by other participating NIH Institutes, is offering an R01 grant opportunity focused on secondary analysis and integration of existing data to better understand cancer risk and cancer-related outcomes. The central idea is to fund research teams that can answer important, high-impact cancer questions by reusing and creatively combining data that already exist, rather than collecting new primary data. This funding opportunity is explicitly labeled "Clinical Trial Not Allowed," meaning the supported work should not involve initiating or conducting clinical trials; instead, the emphasis is on analyzing pre-existing datasets, repositories, and database resources to generate new insights.

Projects supported under this opportunity should aim to elucidate cancer risk and related outcomes across the cancer continuum. Examples of relevant outcomes include identifying or refining factors that predict cancer risk, improving models that estimate individual or population-level risk, uncovering insights that support risk reduction or prevention strategies, evaluating survival differences and drivers of mortality, and studying response to treatment using existing clinical or real-world data sources. The opportunity is broad by design: it welcomes studies that tackle key scientific questions in cancer by mining, linking, and integrating diverse data types, including clinical data, environmental exposure information, cancer surveillance and registry data, health services and healthcare utilization data, vital statistics, behavioral and lifestyle datasets, and genomic and molecular profile data.

A major theme is innovation in how existing data are leveraged. Applicants are encouraged to go beyond straightforward reanalysis and propose approaches that bring new value to current resources. That can include proposing brand-new research aims that are feasible using already available data, applying new or advanced analytic methods to address limitations in prior work, or integrating multiple datasets in novel ways to examine questions that cannot be answered by any single dataset alone. In practice, this could mean harmonizing variables across cohorts, linking clinical records with environmental or neighborhood-level measures, combining molecular profiles with outcomes from registries, or using modern statistical and computational methods to improve prediction, causal inference, or subgroup discovery, all while staying within the scope of secondary data research.

The mechanism is an NIH R01 (research project grant), which typically supports substantial, hypothesis-driven research projects. The award ceiling listed for this opportunity is $350,000 (as provided in the source information), and the agency indicates an original closing date of 2026-09-07. The opportunity number is PAR-25-095, and it falls under discretionary grant funding. It is associated with multiple CFDA numbers (93.121, 93.172, 93.393, 93.866), reflecting the participation of NIH components and program areas connected to cancer and related health research.

Eligibility is intentionally expansive, reflecting an interest in drawing strong proposals from a wide range of organizations that can responsibly manage and analyze complex datasets. Eligible applicants include many types of U.S. governmental entities (state, county, city/township, special district governments, and independent school districts), public and state-controlled institutions of higher education, private institutions of higher education, federally recognized Native American tribal governments, tribal organizations that are not federally recognized, public housing authorities/Indian housing authorities, nonprofits both with and without 501(c)(3) status (other than institutions of higher education), for-profit organizations (other than small businesses), and small businesses. The notice also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-U.S. entities (foreign organizations). This broad eligibility signals that the NIH is open to strong analytic teams wherever they sit, including institutions that serve underrepresented communities and organizations positioned to address cancer disparities using existing data.

Overall, this grant opportunity is designed for researchers who can extract new, policy- or practice-relevant cancer knowledge from data that are already collected, whether those data come from clinical care, public health surveillance, population studies, or biomedical profiling efforts. Competitive applications will likely be those that articulate a clear and important cancer question, justify why existing data are sufficient and well-suited to answer it, propose rigorous and innovative analytic or integration strategies, and show a credible plan for managing data access, quality, harmonization, and interpretation, all without crossing into conducting a clinical trial.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.172, 93.393, 93.866.
• This funding opportunity was created on 2024-11-18.
• Applicants must submit their applications by 2026-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $350,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

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